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KMID : 1134820180470020123
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Journal of the Korean Society of Food Science and Nutrition
2018 Volume.47 No. 2 p.123 ~ p.130
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Effects of Ramie Leaves on Regulation of Osteoporosis in Ovariectomized Mice
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Kim Nam-Seok
Kim Ha-Rim
Lee Deug-Joo
Jeong Chi-Hyoung
Oh Mi-Jin
Kim Jong-Seok
Kwon Jin
Kim Myoung-Soon
Oh Chan-Ho
Lee Chang-Hyun
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Abstract
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The objectives of this study were to investigate the effects of Ramie leaves (RL) on bone metabolism in ovariectomized (OVX) mice. Female mice weighing 20∼25 g each were assigned to six experimental groups: Sham-operated group (Sham group), OVX control group (OVX group), OVX mice fed calcium-free diet with 5% (RL5% group) or 10% (RL10% group) RL supplemented diet, and administered ramie extract (RLext group, 1,000 mg/kg, p.o.). After 12 weeks, all experimental groups demonstrated significantly increased bone mineral density and trabecular thickness, and the RL10% and RLext groups showed significantly increased bone volume/tissue volume and trabecular number. This study attempted to use a physiological analysis method to analyze the serum osteocalcin and C-telopeptide contents of type Ⅰ collagen (CTX-1). The osteocalcin concentration was significantly reduced in both the RL5% group (28.6%) and RL10% group (36.5%) compared to the OVX group. The CTX-1 concentration was significantly reduced in both the RL5% group (43.5%) and RL10% group (42.9%) compared to the OVX group. These results suggest that RL might improve the structural parameters of trabecular bone and bone mineral density, as well as reduce bone formation and bone resorption factors. Therefore, RL could be applied as a functional food material for prevention of osteoporosis.
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KEYWORD
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Boehmeria nivea (Ramie), osteoporosis, CTX-1, osteocalcin, micro-CT
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